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Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

Oncogene 36, 3661 (29 June 2017). doi:10.1038/onc.2016.519

Authors: Y Obata, K Horikawa, T Takahashi, Y Akieda, M Tsujimoto, J A Fletcher, H Esumi, T Nishida & R Abe

Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia

Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia

Oncogene 36, 3651 (29 June 2017). doi:10.1038/onc.2016.515

Authors: M H A van Attekum, S Terpstra, E Slinger, M von Lindern, P D Moerland, A Jongejan, A P Kater & E Eldering

Analysis: For GOP Congress, an imperative on health care
Republicans anticipate a major backlash from GOP voters if they don't make good on the promises that swept them to control of the House and Senate and helped propel Donald Trump to the White House in last year's elections. Trump himself could turn on his congressional allies if they fail, some Republicans fear, and take his supporters with him just as the 2018 midterm elections loom. [...] passage of health care legislation would set the stage for the next major item on Trump's to-do list: rewriting the loophole-ridden U.S. tax code. Perhaps most importantly, after making it through six months without a single marquee legislative achievement, health legislation now looms as a make-or-break test of the GOP's ability to govern now that it controls the levers of power in Washington. GOP senators are keenly aware of such considerations in the wake of McConnell's decision to cancel votes planned for this week on his bill to repeal core elements of Obama's Affordable Care Act. In addition to tax legislation, lawmakers face looming deadlines on must-pass budget bills and will have to raise the government's debt limit or face an unprecedented default. The cuts in Medicaid funding contained in the bill coincide with the opioid epidemic ravaging some areas of the country, including in states like West Virginia and Ohio, where vulnerable residents rely on government health coverage.
Cyberattack: Shipping giant's terminals slowly recovering
COPENHAGEN, Denmark (AP) — Danish shipping giant A.P. Moller-Maersk, one of the global companies hardest hit by a malicious software that froze computers around the globe, said Thursday that most of its terminals are now operational, though some remain crippled. The shipping company is one of a number of major corporations and government agencies — from logistics firm FedEx to Ukraine's banking system — to have been hit by the software epidemic. That hunch was buttressed by the way the malware appears to have been seeded using a rogue update to a piece of Ukrainian accounting software — suggesting an attacker focused on Ukrainian targets. [...] it comes on the anniversary of the assassination of a senior Ukrainian military intelligence officer and a day before a national holiday celebrating a new constitution signed after the breakup of the Soviet Union.
As South Sudan's civil war rages, cholera takes deadly toll
Twenty-four hours earlier, the couple had arrived at the clinic in Pieri, a rebel-held town in South Sudan's Jonglei state and part of what the United Nations calls "the longest, most widespread and most deadly cholera outbreak" since the country won independence in 2011. Since this outbreak began one year ago, over 11,000 cases have been reported, including at least 190 deaths, according to the World Health Organization and South Sudan's government. WHO says 2017 shows a slight increase in cases, which coincides with the recent surge of displaced people across the country as civil war moves well into its fourth year. The situation will only get worse without consistent humanitarian access, says Doctors Without Borders, the only foreign aid organization with a presence in Pieri. The civil war has displaced an estimated two million people inside the country and sent another two million fleeing to neighboring nations in what the United Nations has called the world's fastest growing refugee crisis. The mass displacement of people, like the civil war itself, shows no signs of slowing.
Online hate speech may soon incur a hefty bill in Germany
The U.N.'s independent expert on freedom of speech, David Kaye, warned the German government earlier this month that the criteria for removing material were "vague and ambiguous," adding that the prospect of hefty fines could prompt social media companies such as Facebook and Twitter to delete questionable content without waiting for a court to rule it's unlawful. After World War II, the country criminalized Holocaust denial and any glorification of its Nazi past, citing the genocidal results such ideas produced as proof of the need to ban them from public debate. Calls to commit murder, threats, insults, incitement to hatred or the Auschwitz-lie (that Nazi death camps didn't exist) aren't expressions of freedom of opinion but attacks on the freedom of opinion of others. Maas blames unbridled social media for stoking tensions that have spilled into real-life violence such as arson attacks on asylum-seeker homes and attempts to kill pro-migrant politicians. Declining to provide her real name for fear of being targeted by political opponents, she described Twitter as a place for getting unfiltered, real-time information about crimes committed by immigrants — an issue she claims mainstream media suppress. — Companies can delegate the review process to an independent third party overseen by the Justice Ministry— a concession to critics who warned against putting censorship in the hands of private companies. Twitter and Facebook insist they are trying to address the problem of illegal content and hate speech, conscious of the fact that Germany's justice minister wants to take regulation to the European level as a next step. The company has faced a backlash elsewhere for perceived over-zealous removal of content, such as in the case of AP photographer Nick Ut's iconic "Napalm girl" photo taken during the Vietnam War of a naked girl fleeing an attack.
Ras–Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function

Ras–Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function

Oncogene 36, 3729 (29 June 2017). doi:10.1038/onc.2016.517

Authors: T Zahavi, A Maimon, T Kushnir, R Lange, E Berger, D Kornspan, R Grossman, S Anzi, E Shaulian, R Karni, H Nechushtan & Z Paroush

C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition

C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition

Oncogene 36, 3718 (29 June 2017). doi:10.1038/onc.2016.505

Authors: A Cannistraci, G Federici, A Addario, A L Di Pace, L Grassi, G Muto, D Collura, M Signore, L De Salvo, S Sentinelli, G Simone, M Costantini, S Nanni, A Farsetti, V Coppola, R De Maria & D Bonci

A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial–mesenchymal transition in cancer

A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial–mesenchymal transition in cancer

Oncogene 36, 3706 (29 June 2017). doi:10.1038/onc.2016.504

Authors: N V Sankpal, T P Fleming, P K Sharma, H J Wiedner & W E Gillanders

CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling

CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling

Oncogene 36, 3695 (29 June 2017). doi:10.1038/onc.2016.525

Authors: C Lin, W Liao, Y Jian, Y Peng, X Zhang, L Ye, Y Cui, B Wang, X Wu, Z Xiong, S Wu, J Li, X Wang & L Song

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