Source: DARE
Area: Evidence > Disease Focused Reviews
CRD Summary: The review assessed the effectiveness of biphosphonates for the treatment of CRPS 1 patients with bone loss. It concluded that very limited available data suggested that biphosphonates had the potential to reduce pain associated with bone loss in CRPS 1 patients. The conclusions reflect the limited data presented and are appropriate.
CRD Commentary: The review question was clear with respect to study design, participants, interventions and outcomes. Relevant databases were searched without language restriction, thus minimising the possibility of language bias. Relevant studies may have been missed as no attempts were made to search for unpublished literature. Potential for reviewer bias and error was minimised through duplicate study selection, data extraction and quality assessment. Characteristics and quality of the individual studies were presented clearly. Methods used to synthesize results were appropriately justified, but results of statistical pooling were ...
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